9F6H

Crystal structure of bovine alpha-chymotrypsin in complex with the bicyclic peptide inhibitor MP5.4.3

Summary for 9F6H

• Entry DOI: 10.2210/pdb9f6h/pdb
• Descriptor: Chymotrypsin A chain A, Chymotrypsin A chain B, Chymotrypsin A chain C, ... (5 entities in total)
• Functional Keywords: serine protease; bicyclic peptide, hydrolase
• Biological source: Bos taurus (cattle); More
• Total number of polymer chains: 4
• Total formula weight: 26707.31

Authors

Vascon, F.,Mazzocato, Y.,Trevisan, L.,Linciano, S.,Romanyuk, Z.,Angelini, A.,Cendron, L. (deposition date: 2024-05-01, release date: 2025-05-28)

• Primary citation: Linciano, S.,Mazzocato, Y.,Romanyuk, Z.,Vascon, F.,Farrera-Soler, L.,Will, E.,Xing, Y.,Chen, S.,Kumada, Y.,Simeoni, M.,Scarso, A.,Cendron, L.,Heinis, C.,Angelini, A.; Screening macrocyclic peptide libraries by yeast display allows control of selection process and affinity ranking; Nat Commun, 2025

Experimental method

X-RAY DIFFRACTION (2.42 Å)