9F5V

Crystal structure of thiol peroxidase from Helicobacter pylori (HpTx, reduced)

Summary for 9F5V

• Entry DOI: 10.2210/pdb9f5v/pdb
• Related: 1PSQ
• Descriptor: Thiol peroxidase (2 entities in total)
• Functional Keywords: stress response, detoxification, active site analysis, protein inhibitor interactions, catalysis, drug target, oxidoreductase
• Biological source: Helicobacter pylori
• Total number of polymer chains: 2
• Total formula weight: 41477.97

Authors

Fiedler, M.K.,Gong, R.,Fuchs, S.,Rox, K.,Friedrich, V.,Pfeiffer, D.,Reinhardt, T.,Mibus, C.,Huber, M.,Hess, C.,Mejias-Luque, R.,Gerhard, M.,Groll, M.,Sieber, S.A. (deposition date: 2024-04-30, release date: 2025-05-14)

• Primary citation: Fiedler, M.K.,Gong, R.,Fuchs, S.,Rox, K.,Friedrich, V.,Pfeiffer, D.,Reinhardt, T.,Mibus, C.,Huber, M.,Hess, C.,Mejias-Luque, R.,Gerhard, M.,Groll, M.,Sieber, S.A.; 5-Nitroimidazole ethers boost anti-Helicobacter pylori activity via a dual mode of action and effectively eradicate infections in vivo; to be published,

Experimental method

X-RAY DIFFRACTION (1.75 Å)