9F5H

Crystal structure of MGAT5 bump-and-hole mutant in complex with UDP and M592

Summary for 9F5H

Entry DOI	10.2210/pdb9f5h/pdb
Descriptor	Secreted alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A, URIDINE-5'-DIPHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	bump and hole, bioorthogonal tag, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	119420.74
Authors	Liu, Y.,Bineva-Todd, G.,Meek, R.,Mazo, L.,Piniello, B.,Moroz, O.V.,Begum, N.,Roustan, C.,Tomita, S.,Kjaer, S.,Rovira, C.,Davies, G.J.,Schumann, B. (deposition date: 2024-04-28, release date: 2024-10-02)
Primary citation	Liu, Y.,Bineva-Todd, G.,Meek, R.W.,Mazo, L.,Piniello, B.,Moroz, O.,Burnap, S.A.,Begum, N.,Ohara, A.,Roustan, C.,Tomita, S.,Kjaer, S.,Polizzi, K.,Struwe, W.B.,Rovira, C.,Davies, G.J.,Schumann, B. A Bioorthogonal Precision Tool for Human N -Acetylglucosaminyltransferase V. J.Am.Chem.Soc., 2024 Cited by PubMed: 39287665 DOI: 10.1021/jacs.4c05955 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.97 Å)

Structure validation