9F5H

Crystal structure of MGAT5 bump-and-hole mutant in complex with UDP and M592

9F5H の概要

• エントリーDOI: 10.2210/pdb9f5h/pdb
• 分子名称: Secreted alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A, URIDINE-5'-DIPHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: bump and hole, bioorthogonal tag, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 119420.74

構造登録者

Liu, Y.,Bineva-Todd, G.,Meek, R.,Mazo, L.,Piniello, B.,Moroz, O.V.,Begum, N.,Roustan, C.,Tomita, S.,Kjaer, S.,Rovira, C.,Davies, G.J.,Schumann, B. (登録日: 2024-04-28, 公開日: 2024-10-02)

• 主引用文献: Liu, Y.,Bineva-Todd, G.,Meek, R.W.,Mazo, L.,Piniello, B.,Moroz, O.,Burnap, S.A.,Begum, N.,Ohara, A.,Roustan, C.,Tomita, S.,Kjaer, S.,Polizzi, K.,Struwe, W.B.,Rovira, C.,Davies, G.J.,Schumann, B.; A Bioorthogonal Precision Tool for Human N -Acetylglucosaminyltransferase V.; J.Am.Chem.Soc., 2024; PubMed: 39287665; DOI: 10.1021/jacs.4c05955

実験手法

X-RAY DIFFRACTION (1.97 Å)