9F43

cryo-EM structure of human LST2 bound to human mTOR complex 1, focused on RAPTOR

Summary for 9F43

• Entry DOI: 10.2210/pdb9f43/pdb
• EMDB information: 50182
• Descriptor: Regulatory-associated protein of mTOR, Lateral signaling target protein 2 homolog (2 entities in total)
• Functional Keywords: mtor, mtorc1, lst2, zfyve28, egfr, tos, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 249369.13

Authors

Craigie, L.M.,Maier, T. (deposition date: 2024-04-26, release date: 2024-08-14)

• Primary citation: Battaglioni, S.,Craigie, L.M.,Filippini, S.,Maier, T.,Hall, M.N.; mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR; Proc.Natl.Acad.Sci.USA, 2024

Experimental method