9F43

cryo-EM structure of human LST2 bound to human mTOR complex 1, focused on RAPTOR

Summary for 9F43

Entry DOI	10.2210/pdb9f43/pdb
EMDB information	50182
Descriptor	Regulatory-associated protein of mTOR, Lateral signaling target protein 2 homolog (2 entities in total)
Functional Keywords	mtor, mtorc1, lst2, zfyve28, egfr, tos, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	249369.13
Authors	Craigie, L.M.,Maier, T. (deposition date: 2024-04-26, release date: 2024-08-14, Last modification date: 2024-08-28)
Primary citation	Battaglioni, S.,Craigie, L.M.,Filippini, S.,Maier, T.,Hall, M.N. mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR. Proc.Natl.Acad.Sci.USA, 121:e2405959121-e2405959121, 2024 Cited by PubMed: 39141345 DOI: 10.1073/pnas.2405959121 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.49 Å)

Structure validation