9EZ9

Crystal structure of human Dihydroorotate Dehydrogenase in complex with the inhibitor N-(3'-(2,2-difluoropropoxy)-2,3,5,6-tetrafluoro-[1,1'-biphenyl]-4-yl)-2-hydroxypyrazolo[1,5-a]pyridine-3-carboxamide

This is a non-PDB format compatible entry.

Summary for 9EZ9

• Entry DOI: 10.2210/pdb9ez9/pdb
• Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, OROTIC ACID, FLAVIN MONONUCLEOTIDE, ... (7 entities in total)
• Functional Keywords: acute myelogenous leukemia dihydroorotate dehydrogenase inhibitors drug discovery, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 44122.62

Authors

Alberti, M.,Miggiano, R. (deposition date: 2024-04-11, release date: 2025-07-23)

• Primary citation: Alberti, M.,Miggiano, R.; Crystal structure of human Dihydroorotate Dehydrogenase in complex with the inhibitor N-(3'-(2,2-difluoropropoxy)-2,3,5,6-tetrafluoro-[1,1'-biphenyl]-4-yl)-2-hydroxypyrazolo[1,5-a]pyridine-3-carboxamide; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.6 Å)