9EX6

CryoEM structure of sTeLIC nanodisc in closed state

Summary for 9EX6

Entry DOI	10.2210/pdb9ex6/pdb
EMDB information	50031
Descriptor	Cys-loop ligand-gated ion channel, DODECANE, N-OCTANE, ... (7 entities in total)
Functional Keywords	ion channel, translocase
Biological source	endosymbiont of Tevnia jerichonana (vent Tica)
Total number of polymer chains	5
Total formula weight	191533.97
Authors	Fan, C.,Howard, R.J.,Lindahl, E. (deposition date: 2024-04-05, release date: 2025-03-26)
Primary citation	Karlsson, E.,Anden, O.,Fan, C.,Fourati, Z.,Haouz, A.,Zhuang, Y.,Howard, R.J.,Delarue, M.,Lindahl, E. Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel. Br.J.Pharmacol., 2025 Cited by PubMed Abstract: Allosteric modulation of pentameric ligand-gated ion channels (pLGICs) are critical for the action of neurotransmitters and many psychoactive drugs. However, details of their modulatory mechanisms remain unclear, especially beyond the orthosteric neurotransmitter-binding sites. The recently reported prokaryotic symbiont of Tevnia jerichonana ligand-gated ion channel (sTeLIC), a pH-gated homologue of eukaryotic receptors in the pLGIC family, is thought to be modulated by aromatic compounds via a relatively uncharacterised modulatory site in the extracellular vestibule. PubMed: 40065647 DOI: 10.1111/bph.70011 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.35 Å)

Structure validation