9EX4

CryoEM structure of sTeLIC nanodisc in complex with fluorinated fos-choline-8 in open state

This is a non-PDB format compatible entry.

Summary for 9EX4

• Entry DOI: 10.2210/pdb9ex4/pdb
• EMDB information: 50030
• Descriptor: Cys-loop ligand-gated ion channel, fluorinated fos-choline-8, HEXANE, ... (5 entities in total)
• Functional Keywords: ion channel, translocase
• Biological source: endosymbiont of Tevnia jerichonana (vent Tica)
• Total number of polymer chains: 5
• Total formula weight: 191689.45

Authors

Fan, C.,Howard, R.J.,Lindahl, E. (deposition date: 2024-04-05, release date: 2025-03-26, Last modification date: 2025-07-09)

Primary citation

Karlsson, E.,Anden, O.,Fan, C.,Fourati, Z.,Haouz, A.,Zhuang, Y.,Howard, R.J.,Delarue, M.,Lindahl, E.
Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel.
Br.J.Pharmacol., 182:2790-2802, 2025

PubMed Abstract: Allosteric modulation of pentameric ligand-gated ion channels (pLGICs) are critical for the action of neurotransmitters and many psychoactive drugs. However, details of their modulatory mechanisms remain unclear, especially beyond the orthosteric neurotransmitter-binding sites. The recently reported prokaryotic symbiont of Tevnia jerichonana ligand-gated ion channel (sTeLIC), a pH-gated homologue of eukaryotic receptors in the pLGIC family, is thought to be modulated by aromatic compounds via a relatively uncharacterised modulatory site in the extracellular vestibule.

PubMed: 40065647
DOI: 10.1111/bph.70011

Experimental method

ELECTRON MICROSCOPY (2.19 Å)