9EUP

Inhibitor-free outward-open structure of Drosophila dopamine transporter

Summary for 9EUP

• Entry DOI: 10.2210/pdb9eup/pdb
• Related: 9EUO
• EMDB information: 19978 19979
• Descriptor: Sodium-dependent dopamine transporter, 9D5 ANTIBODY, HEAVY CHAIN, 9D5 ANTIBODY, LIGHT CHAIN, ... (8 entities in total)
• Functional Keywords: slc6a3, dopamine transporter, neurotransmitter sodium symporters, membrane protein
• Biological source: Drosophila melanogaster (fruit fly); More
• Total number of polymer chains: 3
• Total formula weight: 113778.42

Authors

Pedersen, C.N.,Yang, F.,Ita, S.,Xu, Y.,Akunuri, R.,Trampari, S.,Neumann, C.M.T.,Desdorf, L.M.,Schioett, B.,Salvino, J.M.,Mortensen, O.V.,Nissen, P.,Shahsavar, A. (deposition date: 2024-03-27, release date: 2024-07-24)

• Primary citation: Pedersen, C.N.,Yang, F.,Ita, S.,Xu, Y.,Akunuri, R.,Trampari, S.,Neumann, C.M.T.,Desdorf, L.M.,Schiott, B.,Salvino, J.M.,Mortensen, O.V.,Nissen, P.,Shahsavar, A.; Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site.; J.Neurochem., 2024; PubMed: 39010681; DOI: 10.1111/jnc.16179

Experimental method

ELECTRON MICROSCOPY (3 Å)