9EUP
Inhibitor-free outward-open structure of Drosophila dopamine transporter
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Sodium-dependent dopamine transporter | polymer | 543 | 60939.5 | 1 | UniProt (Q7K4Y6) In PDB | Drosophila melanogaster (fruit fly) | Protein fumin |
| 2 | H | 9D5 ANTIBODY, HEAVY CHAIN | polymer | 240 | 25921.3 | 1 | Mus musculus | ||
| 3 | L | 9D5 ANTIBODY, LIGHT CHAIN | polymer | 237 | 25840.6 | 1 | Mus musculus | ||
| 4 | A | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) | |||
| 5 | A | TRIS-HYDROXYMETHYL-METHYL-AMMONIUM | non-polymer | 122.1 | 1 | Chemie (144) | |||
| 6 | A | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 7 | A | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 8 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) |
Sequence modifications
A: 21 - 601 (UniProt: Q7K4Y6)
| PDB | External Database | Details |
|---|---|---|
| Met 20 | - | initiating methionine |
| Ala 74 | Val 74 | engineered mutation |
| - | Asn 164 | deletion |
| - | Ala 165 | deletion |
| - | Ser 166 | deletion |
| - | Arg 167 | deletion |
| - | Val 168 | deletion |
| - | Pro 169 | deletion |
| - | Val 170 | deletion |
| - | Ile 171 | deletion |
| - | Gly 172 | deletion |
| - | Asn 173 | deletion |
| - | Tyr 174 | deletion |
| - | Ser 175 | deletion |
| - | Asp 176 | deletion |
| - | Leu 177 | deletion |
| - | Tyr 178 | deletion |
| - | Ala 179 | deletion |
| - | Met 180 | deletion |
| - | Gly 181 | deletion |
| - | Asn 182 | deletion |
| - | Gln 183 | deletion |
| - | Ser 184 | deletion |
| - | Leu 185 | deletion |
| - | Leu 186 | deletion |
| - | Tyr 187 | deletion |
| - | Asn 188 | deletion |
| - | Glu 189 | deletion |
| - | Thr 190 | deletion |
| - | Tyr 191 | deletion |
| - | Met 192 | deletion |
| - | Asn 193 | deletion |
| - | Gly 194 | deletion |
| - | Ser 195 | deletion |
| - | Ser 196 | deletion |
| - | Leu 197 | deletion |
| - | Asp 198 | deletion |
| - | Thr 199 | deletion |
| - | Ser 200 | deletion |
| - | Ala 201 | deletion |
| - | Val 202 | deletion |
| - | Gly 203 | deletion |
| - | His 204 | deletion |
| - | Val 205 | deletion |
| - | Glu 206 | deletion |
| Ala 275 | Val 275 | engineered mutation |
| Ala 311 | Val 311 | engineered mutation |
| Ala 415 | Leu 415 | engineered mutation |
| Leu 538 | Gly 538 | engineered mutation |
| Leu 602 | - | expression tag |
| Val 603 | - | expression tag |
| Pro 604 | - | expression tag |
| Arg 605 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 112701.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1077.0 | |
| All* | Total formula weight | 113778.4 |
