9ESC

Holo IDO with a bound inhibitor

This is a non-PDB format compatible entry.

Summary for 9ESC

• Entry DOI: 10.2210/pdb9esc/pdb
• Descriptor: Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, (~{S})-[(7~{a}~{R})-2-cyclopentyl-5,6,7,7~{a}-tetrahydroimidazo[5,1-b][1,3]thiazol-3-yl]-cyclohexyl-methanol, ... (4 entities in total)
• Functional Keywords: inhibitor, heme, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 96020.15

Authors

Wicki, M.,Mac Sweeney, A. (deposition date: 2024-03-26, release date: 2025-03-05)

• Primary citation: Cren, S.,Lotz, C.,Mac Sweeney, A.,Lange, R.,Kimmerlin, T.; SAR and cellular potency optimization of novel heme-binding IDO1 inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.95 Å)