9ENG
Structure of K.pneumoniae LpxH in complex with EBL-3218
This is a non-PDB format compatible entry.
Summary for 9ENG
Entry DOI | 10.2210/pdb9eng/pdb |
Descriptor | UDP-2,3-diacylglucosamine hydrolase, MANGANESE (II) ION, ~{N}-[4-[4-[3,5-bis(chloranyl)phenyl]piperazin-1-yl]sulfonylphenyl]-3-(methylsulfonylamino)benzamide, ... (4 entities in total) |
Functional Keywords | lipid a biosynthesis pathway endotoxin udp-diacyl-glucosamine lipid x gram-negative bacteria antibiotic lipopolysaccharides, hydrolase |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 28702.33 |
Authors | Sooriyaarachchi, S.,Bergfors, T.,Jones, T.A.,Mowbray, S.L. (deposition date: 2024-03-12, release date: 2024-09-18) |
Primary citation | Benediktsdottir, A.,Sooriyaarachchi, S.,Cao, S.,Ottosson, N.E.,Lindstrom, S.,Lundgren, B.,Kloditz, K.,Lola, D.,Bobileva, O.,Loza, E.,Hughes, D.,Jones, T.A.,Mowbray, S.L.,Zamaratski, E.,Sandstrom, A.,Karlen, A. Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors. Eur.J.Med.Chem., 278:116790-116790, 2024 Cited by PubMed: 39236497DOI: 10.1016/j.ejmech.2024.116790 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report