9EML
SARS-CoV-2 methyltransferase nsp10-16 in complex with SAM and m7GpppA (Cap0-analog)/m7GpppAm (Cap1-analog)
Summary for 9EML
Entry DOI | 10.2210/pdb9eml/pdb |
Related | 8BSD 8BZV 8C5M 8OSX 8OT0 8OTR 8OV1 |
Descriptor | 2'-O-methyltransferase nsp16, Non-structural protein 10, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, ... (10 entities in total) |
Functional Keywords | methyltransferase, complex, inhibitor, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 More |
Total number of polymer chains | 2 |
Total formula weight | 52422.60 |
Authors | Kremling, V.,Sprenger, J.,Oberthuer, D.,Kiene, A. (deposition date: 2024-03-08, release date: 2024-03-20) |
Primary citation | Kremling, V.,Sprenger, J.,Oberthuer, D.,Chapman, H.N.,Middendorf, P.,Fernandez-Garcia, Y.,Ehrt, C.,Falke, S.,Kiene, A.,Klopprogge, B.,Scheer, T.E.S.,Rarey, M.,Barthels, F.,Kuehn, S.,Guenther, S. SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug development To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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