9EML

SARS-CoV-2 methyltransferase nsp10-16 in complex with SAM and m7GpppA (Cap0-analog)/m7GpppAm (Cap1-analog)

9EML の概要

• エントリーDOI: 10.2210/pdb9eml/pdb
• 関連するPDBエントリー: 8BSD 8BZV 8C5M 8OSX 8OT0 8OTR 8OV1
• 分子名称: 2'-O-methyltransferase nsp16, Non-structural protein 10, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, ... (10 entities in total)
• 機能のキーワード: methyltransferase, complex, inhibitor, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 52422.60

構造登録者

Kremling, V.,Sprenger, J.,Oberthuer, D.,Kiene, A. (登録日: 2024-03-08, 公開日: 2024-03-20)

• 主引用文献: Kremling, V.,Sprenger, J.,Oberthuer, D.,Chapman, H.N.,Middendorf, P.,Fernandez-Garcia, Y.,Ehrt, C.,Falke, S.,Kiene, A.,Klopprogge, B.,Scheer, T.E.S.,Rarey, M.,Barthels, F.,Kuehn, S.,Guenther, S.; SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug development; To Be Published,

実験手法

X-RAY DIFFRACTION (2.4 Å)