9ELC

Structure of glucocerebrosidase in complex with a covalent inhibitor

This is a non-PDB format compatible entry.

Summary for 9ELC

• Entry DOI: 10.2210/pdb9elc/pdb
• Descriptor: Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: glucocerebrosidase, cerezyme, gaucher disease, glycoside hydrolase, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 116447.47

Authors

Pluvinage, B.,Boraston, A.B. (deposition date: 2024-12-04, release date: 2026-07-08)

• Primary citation: Wang, S.,Tavassoly, O.,Chowdhury, M.A.,Carter, L.,Brown, D.,Bravo, R.C.,Zhang, Z.,Tesolin, D.,Quartey, M.A.,Pluvinage, B.,Nyarko, J.N.,Kumar, M.,Feldman, R.A.,Boraston, A.B.,Mousseau, D.D.,van der Spoel, A.C.,Phenix, C.P.; Irreversible inhibitors and activity-based probes, derived from an adaptable conduritol aziridine scaffold, for studying glucocerebrosidase and GBA2 in vitro and in vivo; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)