9EHM

Structure of HIV-1 BG505 SOSIP.664 Env trimer in complex with IOMAmin5 and 10-1074 Broadly Neutralizing Antibodies - Class II

Summary for 9EHM

• Entry DOI: 10.2210/pdb9ehm/pdb
• EMDB information: 48060
• Descriptor: HIV-1 BG505 SOSIP gp120,Envelope glycoprotein gp120, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (13 entities in total)
• Functional Keywords: hiv-1, env, bnab, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 16
• Total formula weight: 373969.97

Authors

Dam, K.A.,Yang, Z.,Bjorkman, P.J. (deposition date: 2024-11-23, release date: 2025-05-21)

• Primary citation: Dam, K.M.A.,Gristick, H.B.,Li, Y.E.,Yang, Z.,Gnanapragasam, P.N.,West, A.P.,Seaman, M.S.,Bjorkman, P.J.; Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design; Cell Rep, 44:115713-, 2025; DOI: 10.1016/j.celrep.2025.115713

Experimental method

ELECTRON MICROSCOPY (4.2 Å)