9EGK

E3 ubiquitin ligase HUWE1 homolog Tom1p in closed-conformation with internal Acidic Domain deletion

Summary for 9EGK

Entry DOI	10.2210/pdb9egk/pdb
EMDB information	47989
Descriptor	E3 ubiquitin-protein ligase TOM1 (1 entity in total)
Functional Keywords	alpha solenoid, e3 ubiquitin ligase, stress response, cell-cycle, gene regulation
Biological source	Saccharomyces cerevisiae (brewer's yeast)
Total number of polymer chains	1
Total formula weight	375512.59
Authors	Madrigal, J.M. (deposition date: 2024-11-21, release date: 2025-10-01)
Primary citation	Madrigal, J.,Schubert, H.L.,Sdano, M.A.,McCullough, L.,Connell, Z.,Formosa, T.,Hill, C.P. Tom1p ubiquitin ligase structure, interaction with Spt6p, and function in maintaining normal transcript levels and the stability of chromatin in promoters Elife, 2024 Cited by DOI: 10.7554/elife.101393.1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.07 Å)

Structure validation