9EBS

Cryo-EM structure of USP1-UAF1-Ubiquitin in complex with TNG348

This is a non-PDB format compatible entry.

Summary for 9EBS

• Entry DOI: 10.2210/pdb9ebs/pdb
• EMDB information: 47889
• Descriptor: Ubiquitin, WD repeat-containing protein 48, Ubiquitin carboxyl-terminal hydrolase 1, ... (6 entities in total)
• Functional Keywords: deubiquitination, pcna, allosteric inhibitor, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 175041.61

Authors

Whittington, D.A. (deposition date: 2024-11-13, release date: 2025-01-29)

• Primary citation: Simoneau, A.,Pratt, C.B.,Wu, H.-J.,Rajeswaran, S.S.,Comer, C.G.,Sudsakorn, S.,Zhang, W.,Liu, S.,Meier, S.R.,Choi, A.,Khendu, T.,Stowe, H.,Shen, B.,Whittington, D.A.,Chen, Y.,Yu, Y.,Mallender, W.D.,Feng, T.,Andersen, J.N.,Maxwell, J.P.,Throner, S.; Characterization of TNG348: a selective, allosteric USP1 inhibitor that synergizes with PARP inhibitors in tumors with homologous recombination deficiency; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.3 Å)