9E8Y

Complex fibril structure of MSA alpha-synuclein with CNS-11g at 15 hours

This is a non-PDB format compatible entry.

Summary for 9E8Y

• Entry DOI: 10.2210/pdb9e8y/pdb
• EMDB information: 47735
• Descriptor: Alpha-synuclein, 2-(4-benzyl-1-oxophthalazin-2(1H)-yl)-N-(2,6-dimethylphenyl)acetamide (2 entities in total)
• Functional Keywords: complex structure of alpha-synuclein type i with small molecule cns-11g incubated for 15 hours., structural protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 146748.43

Authors

Lu, J.,Sawaya, M.R.,Ge, P.,Boyer, D.R.,Eisenberg, D.S. (deposition date: 2024-11-06, release date: 2025-11-12)

• Primary citation: Lu, J.,Sawaya, M.R.,Cheng, X.Y.,Murrali, M.G.,Ge, P.,Jiang, Y.X.,Cascio, D.,Lutter, L.,Boyer, D.R.,Williams, C.K.,Shino, M.,Feigon, J.,Chaturvedi, S.,Alexandrova, A.,Eisenberg, D.S.; The small molecule CNS-11g forms amyloid-like fibrils that disassemble pathological alpha-synuclein fibrils; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.9 Å)