9E8U

(Apo)Alpha-synuclein fibril structures from MSA patient brain

Summary for 9E8U

• Entry DOI: 10.2210/pdb9e8u/pdb
• EMDB information: 47731
• Descriptor: Alpha-synuclein (1 entity in total)
• Functional Keywords: multiple system atrophy type i alpha-synuclein fibrils., structural protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 144761.08

Authors

Lu, J.,Sawaya, M.R.,Ge, P.,Boyer, D.R.,Eisenberg, D.S. (deposition date: 2024-11-06, release date: 2025-11-12)

• Primary citation: Lu, J.,Sawaya, M.R.,Cheng, X.Y.,Murrali, M.G.,Ge, P.,Jiang, Y.X.,Cascio, D.,Lutter, L.,Boyer, D.R.,Williams, C.K.,Shino, M.,Feigon, J.,Chaturvedi, S.,Alexandrova, A.,Eisenberg, D.S.; The small molecule CNS-11g forms amyloid-like fibrils that disassemble pathological alpha-synuclein fibrils; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.6 Å)