9E2A

Glucagon Like Peptide Receptor-1 (GLP1R) A316T mutant with GLP-1 peptide. Dominant negative Gs complex.

Summary for 9E2A

• Entry DOI: 10.2210/pdb9e2a/pdb
• EMDB information: 47447
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr, glp1, glp-1r, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 167300.47

Authors

Deane-Alder, K.,Belousoff, M.J.,Wootten, D.L. (deposition date: 2024-10-22, release date: 2025-10-29)

• Primary citation: Eid, L.I.,Deane-Alder, K.,Rujan, R.-M.,Mariam, Z.,Oqua, A.I.,Manchanda, Y.,Belousoff, M.J.,Serna, J.B.,Sloop, K.W.,Rutter, G.A.,Montoya, A.,Withers, D.J.,Millership, S.J.,Bouzakri, K.,Jones, B.,Reynolds, C.A.,Sexton, P.M.,Deganutti, G.,Wootten, D.L.,Tomas, A.; In vivo functional profiling and structural characterisation of the human Glp1r A316T variant; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.3 Å)