9DU1
Co-crystal structure of the ternary complex of human FKBP12, BRD9 bromo domain and Compound 1
This is a non-PDB format compatible entry.
Summary for 9DU1
| Entry DOI | 10.2210/pdb9du1/pdb |
| Related | 2dtw |
| Descriptor | Peptidyl-prolyl cis-trans isomerase FKBP1A, Bromodomain-containing protein 9, 4-[4-{cyclopropyl[(1-methyl-1H-pyrazol-4-yl)methyl]amino}-6-({1-[(2R)-2-{[(2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carbonyl]amino}-4-(4-methoxyphenyl)butanoyl]piperidin-4-yl}amino)-1,3,5-triazin-2-yl]-N-ethylpiperazine-1-carboxamide, ... (5 entities in total) |
| Functional Keywords | fkbp12, brd9, bromo domain, glue degrader, ligase |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 8 |
| Total formula weight | 105253.58 |
| Authors | |
| Primary citation | Zandi, T.A.,Tan, Z.R.,Romanowski, M.J.,Viscomi, J.S.,Tong, B.Q.,Bonazzi, S.,Zecri, F.J.,Schreiber, S.L.,Michaud, G.A. Ternary complex DNA-encoded library screening uncovers FKBP molecular glues To Be Published, |
| Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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