9DTW

Co-crystal structure of the ternary complex of human FKBP12, QDPR and Compound 4

This is a non-PDB format compatible entry.

Summary for 9DTW

• Entry DOI: 10.2210/pdb9dtw/pdb
• Descriptor: Dihydropteridine reductase, Peptidyl-prolyl cis-trans isomerase FKBP1A, GLYCEROL, ... (6 entities in total)
• Functional Keywords: fkbp12, qdpr, glue degrader, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 38977.99

Authors

Romanowski, M.J.,Viscomi, J.S. (deposition date: 2024-10-02, release date: 2025-10-08)

• Primary citation: Zandi, T.A.,Tan, Z.R.,Romanowski, M.J.,Viscomi, J.S.,Tong, B.Q.,Bonazzi, S.,Zecri, F.J.,Schreiber, S.L.,Michaud, G.A.; Ternary complex DNA-encoded library screening uncovers FKBP molecular glues; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.39 Å)