9DQD

cryo-EM structure of human Cereblon/DDB1 in complex with a non-traditional CRBN binder

This is a non-PDB format compatible entry.

Summary for 9DQD

• Entry DOI: 10.2210/pdb9dqd/pdb
• EMDB information: 47111
• Descriptor: Protein cereblon, DNA damage-binding protein 1, ZINC ION, ... (4 entities in total)
• Functional Keywords: crl4, ubiquitin, e3, cereblon, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 147335.88

Authors

Zhu, J.,Pagarigan, B. (deposition date: 2024-09-23, release date: 2024-12-25)

• Primary citation: Lejava, A.,Miseo, G.A.,Phan, T.,Zhu, J.,Powers, H.L.,Li, J.,Mortensen, D.S.,Zapf, C.W.,Khambatta, G.,Buenviaje, J.,Holmberg-Douglas, N.; Development of a Buchwald-Hartwig Amination for an Accelerated Library Synthesis of Cereblon Binders; Acs Med.Chem.Lett., 2024; DOI: 10.1021/acsmedchemlett.4c00462

Experimental method

ELECTRON MICROSCOPY (3 Å)