9DNN

Insulin receptor in complex with both insulin and de novo designed site-2 binder "S2B".

Summary for 9DNN

Entry DOI	10.2210/pdb9dnn/pdb
EMDB information	47043
Descriptor	Insulin receptor, Insulin, Designed site-2 binder S2B (3 entities in total)
Functional Keywords	insulin receptor, insulin, designed binder, signaling protein
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	6
Total formula weight	350666.22
Authors	Bai, X.C. (deposition date: 2024-09-17, release date: 2025-10-01)
Primary citation	Bai, X.C. Tuning insulin receptor signaling using de novo designed agonists To Be Published,
Experimental method	ELECTRON MICROSCOPY (6.1 Å)

Structure validation