9DME

Type 3 KD-mxyl filament of miniature tau macrocycle derived from 4R tauopathic fold

Summary for 9DME

• Entry DOI: 10.2210/pdb9dme/pdb
• EMDB information: 47002
• Descriptor: Microtubule-associated protein tau, 1,3-dimethylbenzene (2 entities in total)
• Functional Keywords: tauopathies, neurodegenerative disorders, seed-competent miniature tau macrocycle, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 15
• Total formula weight: 35202.18

Authors

Xu, X.,Angera, J.I.,Rajewski, H.B.,Jiang, W.,Del Valle, R.J. (deposition date: 2024-09-13, release date: 2025-04-23, Last modification date: 2025-05-21)

• Primary citation: Xu, X.,Angera, J.I.,Rajewski, H.B.,Jiang, W.,Del Valle, R.J.; Structure-based design of seed-competent proteomimetic macrocycles derived from 4R tauopathic folds; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.2 Å)