9DME

Type 3 KD-mxyl filament of miniature tau macrocycle derived from 4R tauopathic fold

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	SITE: Not glycated => ECO:0000269|PubMed:9326300

Chain	Residue	Details
J	LYS298
D	LYS311
F	LYS298
F	LYS311
G	LYS298
G	LYS311
I	LYS298
I	LYS311
M	LYS298
M	LYS311
O	LYS298
J	LYS311
O	LYS311
K	LYS298
K	LYS311
N	LYS298
N	LYS311
E	LYS298
E	LYS311
B	LYS298
B	LYS311
H	LYS298
L	LYS298
H	LYS311
L	LYS311
A	LYS298
A	LYS311
C	LYS298
C	LYS311
D	LYS298

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
J	LYS298
D	LYS311
F	LYS298
F	LYS311
G	LYS298
G	LYS311
I	LYS298
I	LYS311
M	LYS298
M	LYS311
O	LYS298
J	LYS311
O	LYS311
K	LYS298
K	LYS311
N	LYS298
N	LYS311
E	LYS298
E	LYS311
B	LYS298
B	LYS311
H	LYS298
L	LYS298
H	LYS311
L	LYS311
A	LYS298
A	LYS311
C	LYS298
C	LYS311
D	LYS298

---

site_id	SWS_FT_FI3
Number of Residues	15
Details	MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:7706316, ECO:0000269|PubMed:8999860

Chain	Residue	Details
J	SER305
O	SER305
K	SER305
N	SER305
E	SER305
B	SER305
H	SER305
L	SER305
A	SER305
C	SER305
D	SER305
F	SER305
G	SER305
I	SER305
M	SER305

---

site_id	SWS_FT_FI4
Number of Residues	15
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
J	LYS298
O	LYS298
K	LYS298
N	LYS298
E	LYS298
B	LYS298
H	LYS298
L	LYS298
A	LYS298
C	LYS298
D	LYS298
F	LYS298
G	LYS298
I	LYS298
M	LYS298

---

site_id	SWS_FT_FI5
Number of Residues	30
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau => ECO:0000269|PubMed:16443603

Chain	Residue	Details
D	LYS311
F	LYS311
G	LYS311
I	LYS311
M	LYS311
J	LYS311
O	LYS311
K	LYS311
N	LYS311
E	LYS311
B	LYS311
H	LYS311
L	LYS311
A	LYS311
C	LYS311

---