9DM9

HIV-RT pre-catalytic complex with MK-8527

This is a non-PDB format compatible entry.

Summary for 9DM9

• Entry DOI: 10.2210/pdb9dm9/pdb
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT, DNA Primer, ... (6 entities in total)
• Functional Keywords: hiv-rt, nrtti, nucleoside reverse transcriptase translocation inhibitor, transferase, transferase-dna complex, transferase/dna
• Biological source: HIV-1 M:B_HXB2R; More
• Total number of polymer chains: 4
• Total formula weight: 133424.18

Authors

Hayes, R.P.,Tummala, S. (deposition date: 2024-09-12, release date: 2025-09-17)

• Primary citation: Raheem, I.,Girijavallabhan, V.,Fillgrove, K.,Goh, S.,Bahnck-Teets, C.,Huang, Q.,Li, F.,Wan, B.,O'Donnell, G.,Patteson, J.,Cilento, M.,Bennet, A.,Bhardwaj, S.,Hayes, R.,Tummala, S.,McHale, C.,Wiltsie, J.,Ellis, J.,Asante-Appiah, E.,Hazuda, D.,Hale, J.,Grobler, J.,Carroll, S.,Xu, M.,Diamond, T.,Lai, M.; Discovery of MK-8527, a novel long-acting nucleoside reverse transcriptase translocation inhibitor of HIV replication; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.73 Å)