9DKK

Designed miniproteins potently inhibit and protect against MERS-CoV. MERS-CoV S in complex with miniprotein cb3_GGGSGGGS_SB175, linker 7 (Local refinement of two RBDs and 2 miniproteins)

This is a non-PDB format compatible entry.

Summary for 9DKK

• Entry DOI: 10.2210/pdb9dkk/pdb
• EMDB information: 46955 46960
• Descriptor: Spike protein, Miniprotein cb3_GGGSGGGS_SB175, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: coronavirus, betacoronavirus, mers-cov, single particle cryo-em, neutralization assays, binding assays, miniproteins inhibitors, fusion assays, in vivo protection, structural genomics, seattle structural genomics center for infectious disease, ssgcid, viral protein
• Biological source: Middle East respiratory syndrome-related coronavirus (MERS-CoV); More
• Total number of polymer chains: 4
• Total formula weight: 334567.86

Authors

Tortorici, M.A.,Seattle Structural Genomics Center for Infectious Disease (SSGCID),Veesler, D. (deposition date: 2024-09-09, release date: 2025-10-15)

• Primary citation: Tortorici, M.A.,Veesler, D.; Designed miniproteins potently inhibit and protect against MERS-CoV. MERS-CoV S in complex with miniprotein cb3_GGGSGGGS_SB175, linker 7 (Local refinement of two RBDs and 2 miniproteins); To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.3 Å)