9DIW

Crystal structure of the SARS-CoV-2 main protease in complex with covalent tripeptidyl inhibitor NIP-22c

This is a non-PDB format compatible entry.

Summary for 9DIW

• Entry DOI: 10.2210/pdb9diw/pdb
• Related: 9D08
• Descriptor: Non-structural protein 7, tripeptidyl inhibitor (3 entities in total)
• Functional Keywords: sars-cov-2 3clpro protease, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, 2019-nCoV); More
• Total number of polymer chains: 2
• Total formula weight: 34289.12

Authors

Engel, J.E.,Al-Homoudi, A.I.,Muczynski, M.D.,Brunzelle, J.S.,Kovari, L.C. (deposition date: 2024-09-06, release date: 2026-03-11)

• Primary citation: Muczynski, M.D.,Engel, J.E.,Al-Homoudi, A.I.,Brunzelle, J.S.,Kovari, L.C.; Similar Free and Complexed Inhibitor Conformations Enhance SARS-CoV-2 3CLpro Inhibitor Efficacy; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.43 Å)