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9DGF

Tetrahydroprotoberberine N-methyltransferase product complex with N-methyltetrahydropalmatine and SAH

This is a non-PDB format compatible entry.
Summary for 9DGF
Entry DOI10.2210/pdb9dgf/pdb
Related9DG6
DescriptorTetrahydroprotoberberine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, N-Methyltetrahydropalmatine, ... (4 entities in total)
Functional Keywordsmethyltransferase, benzylisoquinoline alkaloid, transferase
Biological sourceGlaucium flavum
Total number of polymer chains1
Total formula weight44556.80
Authors
Lang, D.E.,Ng, K.K.S. (deposition date: 2024-09-02, release date: 2025-09-17)
Primary citationLang, D.E.,Ng, K.K.S.,Rehman, F.,Morris, J.S.,Facchini, P.J.
The stereospecific activities of the tetrahydroprotoberberine N-methyltransferase with alternative substrates provide insight into the catalytic mechanisms of benzylisoquinoline alkaloid N-methylation.
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

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