9DDR

Ternary substrate complex of DNA polymerase iota with DNA (template A), Ca2+, and dTTP

Summary for 9DDR

• Entry DOI: 10.2210/pdb9ddr/pdb
• Descriptor: DNA polymerase iota, DNA (5'-D(P*AP*AP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), THYMIDINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: dna, polymerase, lesion, replication
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 53091.24

Authors

Frevert, Z.,Reusch, D.,Freudenthal, B.,Washington, M.T. (deposition date: 2024-08-28, release date: 2025-07-09)

• Primary citation: Frevert, Z.,Reusch, D.T.,Gildenberg, M.S.,Jordan, S.M.,Ryan, B.J.,Freudenthal, B.D.,Washington, M.T.; Visualizing DNA polymerase iota catalyze Hoogsteen-directed DNA synthesis; Nat Commun, 16:5979-, 2025; DOI: 10.1038/s41467-025-61245-8

Experimental method

X-RAY DIFFRACTION (2.15 Å)