9DAV

STING oligomer bound to cGAMP and STG2 in the presence of PI4P

Summary for 9DAV

• Entry DOI: 10.2210/pdb9dav/pdb
• Related: 9DAN 9DAT
• EMDB information: 46699
• Descriptor: Stimulator of interferon genes protein, 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, cGAMP (3 entities in total)
• Functional Keywords: sting, lipid, oligomerization, signaling protein, signaling protein-activator complex, signaling protein/activator
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 160417.48

Authors

Li, J.,Zhang, X.,Bai, X. (deposition date: 2024-08-22, release date: 2025-12-17, Last modification date: 2026-02-04)

• Primary citation: Li, J.,Tan, J.X.,Chen, Z.J.,Zhang, X.,Bai, X.; Regulation of STING activation by phosphoinositide and cholesterol; Nature, 2026; DOI: 10.1038/s41586-025-10076-0

Experimental method

ELECTRON MICROSCOPY (2.8 Å)