9D8S

Crystal Structure of calcium-dependent protein kinase 1 (CDPK1) from Cryptosporidium parvum (AMP/Mg bound)

Summary for 9D8S

• Entry DOI: 10.2210/pdb9d8s/pdb
• Descriptor: Calmodulin-domain protein kinase 1, ADENOSINE MONOPHOSPHATE, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: ssgcid, structural genomics, seattle structural genomics center for infectious disease, transferase, cryptosporidium parvum, cdpk1
• Biological source: Cryptosporidium parvum Iowa II
• Total number of polymer chains: 1
• Total formula weight: 57221.83

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2024-08-20, release date: 2024-09-04, Last modification date: 2026-05-13)

Primary citation

Wijitrmektong, W.,Choi, R.,Hulverson, M.A.,Liu, L.,Cooper, A.,Battaile, K.P.,Harmon, E.K.,Dayao, D.A.,Huerta, L.,Tzipori, S.,McNamara, C.W.,Bakowski, M.A.,Lovell, S.,Van Voorhis, W.C.,Cuny, G.D.
Structure-guided design of calcium-dependent protein kinase 1 (CDPK1) inhibitors for cryptosporidiosis.
J.Infect.Dis., 2026

PubMed Abstract: Calcium-dependent protein kinase 1 (CDPK1) has emerged as a protozoan specific target for the treatment of cryptosporidiosis. A previous study identified pyridopyrimidinones as new Cryptosporidium parvum (Cp) CDPK1 inhibitors with potent growth inhibition against C. parvum and C. hominis. Docking analyses suggested the unique positioning of the kinase's αC-helix could present refinement opportunities.

PubMed: 42081373
DOI: 10.1093/infdis/jiag242

Experimental method

X-RAY DIFFRACTION (2.12 Å)