9CUC

Human STING G230A/R293Q variant bound to THIQi

This is a non-PDB format compatible entry.

Summary for 9CUC

• Entry DOI: 10.2210/pdb9cuc/pdb
• Descriptor: Stimulator of interferon genes protein, (3S,4S)-2-(4-tert-butyl-3-chlorophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid (3 entities in total)
• Functional Keywords: innate immunity, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 147185.21

Authors

Critton, D.A. (deposition date: 2024-07-26, release date: 2025-06-18)

• Primary citation: Xie, T.,Ruzanov, M.,Critton, D.A.,Merselis, L.,Naglich, J.,Sack, J.S.,Zhang, P.,Xie, C.,Tredup, J.,Stine, L.B.,Messier, C.,Caceres-Cortes, J.,Mueller, L.,Dyckman, A.J.,Newitt, J.A.,Wilson, S.C.; Orthosteric STING inhibition elucidates molecular correction of SAVI STING; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.097 Å)