9CTX
X-ray crystal structure of multi-drug resistant HIV-1 protease (P51) in complex with Darunavir
Summary for 9CTX
Entry DOI | 10.2210/pdb9ctx/pdb |
Related | 6MKL |
Descriptor | Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, GLYCEROL, ... (4 entities in total) |
Functional Keywords | hiv-1 protease, viral protein |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 1 |
Total formula weight | 11515.48 |
Authors | Hayashi, H.,Yedidi, R.,Bulut, H.,Das, D.,Mitsuya, H. (deposition date: 2024-07-25, release date: 2024-08-07) |
Primary citation | Das, D.,Hayashi, H.,Yedidi, R.S.,Bulut, H.,Mitsuya, H. Secondary amino-acid substitutions contribute to the emergence of HIV protease inhibitor resistance as directly as primary amino-acid substitutions. To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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