9CTX
X-ray crystal structure of multi-drug resistant HIV-1 protease (P51) in complex with Darunavir
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Protease | polymer | 99 | 10875.7 | 1 | UniProt (O38893) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 | |
2 | A | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | non-polymer | 547.7 | 1 | Chemie (017) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
4 | water | water | 18.0 | 58 | Chemie (HOH) |
Sequence modifications
A: 1 - 99 (UniProt: O38893)
PDB | External Database | Details |
---|---|---|
Ile 32 | Val 32 | conflict |
Phe 33 | Leu 33 | conflict |
Met 54 | Val 54 | conflict |
Ile 82 | Ala 82 | conflict |
Val 84 | Ile 84 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 10875.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 639.8 | |
All* | Total formula weight | 11515.5 |