9CMN

Room-temperature X-ray structure of SARS-CoV-2 main protease drug resistant mutant (E166A, L167F)

Summary for 9CMN

Entry DOI	10.2210/pdb9cmn/pdb
Related	9CMJ
Descriptor	3C-like proteinase nsp5 (2 entities in total)
Functional Keywords	cysteine protease, drug resistant mutant, homodimer, hydrolase
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
Total number of polymer chains	1
Total formula weight	33801.53
Authors	Kovalevsky, A.,Coates, L.,Gerlits, O. (deposition date: 2024-07-15, release date: 2024-10-16)
Primary citation	Kovalevsky, A.,Aniana, A.,Ghirlando, R.,Coates, L.,Drago, V.N.,Wear, L.,Gerlits, O.,Nashed, N.T.,Louis, J.M. Effects of SARS-CoV-2 Main Protease Mutations at Positions L50, E166, and L167 Rendering Resistance to Covalent and Noncovalent Inhibitors. J.Med.Chem., 2024 Cited by PubMed: 39370853 DOI: 10.1021/acs.jmedchem.4c01781 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation