9CKW

X-ray diffraction structure of papain co-crystallized with E-64D

Summary for 9CKW

• Entry DOI: 10.2210/pdb9ckw/pdb
• Related: 9CKT
• Descriptor: Papain, METHANOL, ethyl (3S)-3-hydroxy-4-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}amino)-4-oxobutanoate, ... (4 entities in total)
• Functional Keywords: protease, complex, inhibitor-bound, hydrolase
• Biological source: Carica papaya (papaya)
• Total number of polymer chains: 1
• Total formula weight: 23828.79

Authors

Vlahakis, N.W.,Rodriguez, J.A. (deposition date: 2024-07-10, release date: 2025-06-04)

• Primary citation: Liu, M.,Zang, X.,Vlahakis, N.W.,Rodriguez, J.A.,Ohashi, M.,Tang, Y.; Enzymatic combinatorial synthesis of E-64 and related cysteine protease inhibitors; Nat.Chem.Biol., 2025; DOI: 10.1038/s41589-025-01907-2

Experimental method

X-RAY DIFFRACTION (1.4 Å)