9CJL

Molecular basis of TMED9 dodecamer

Summary for 9CJL

Entry DOI	10.2210/pdb9cjl/pdb
EMDB information	45635
Descriptor	Transmembrane emp24 domain-containing protein 9, [(2R)-2-[(E)-octadec-9-enoyl]oxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] (E)-octadec-9-enoate (2 entities in total)
Functional Keywords	tmed9, misfolded protein, secretory pathway, cryo-em, protein transport
Biological source	Homo sapiens (human)
Total number of polymer chains	12
Total formula weight	329818.87
Authors	Le, X.,Xiong, P. (deposition date: 2024-07-06, release date: 2024-10-02)
Primary citation	Xiao, L.,Pi, X.,Goss, A.C.,El-Baba, T.,Ehrmann, J.F.,Grinkevich, E.,Bazua-Valenti, S.,Padovano, V.,Alper, S.L.,Carey, D.,Udeshi, N.D.,Carr, S.A.,Pablo, J.L.,Robinson, C.V.,Greka, A.,Wu, H. Molecular basis of TMED9 oligomerization and entrapment of misfolded protein cargo in the early secretory pathway. Sci Adv, 10:eadp2221-eadp2221, 2024 Cited by PubMed: 39303030 DOI: 10.1126/sciadv.adp2221 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (5.5 Å)

Structure validation