9CHY

Crystal structure of the human MESH1 (D66K)-PAPS complex

Summary for 9CHY

Entry DOI	10.2210/pdb9chy/pdb
Descriptor	Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1, ZINC ION, 3'-PHOSPHATE-ADENOSINE-5'-PHOSPHATE SULFATE, ... (6 entities in total)
Functional Keywords	phosphatase, paps, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	42296.03
Authors	Rose, J.,Zhou, P. (deposition date: 2024-07-02, release date: 2025-12-10)
Primary citation	Lin, C.-C.,Rose, J.,Zhang, A.,Mirando, A.J.,Mestre, A.A.,Ding, C.C.,Liao, Y.,Chen, S.-Y.,Setayeshpour, Y.,Wu, J.,Li, Z.,Yan, D.,Hilton, M.J.,Zhou, P.,Chi, J.-T. MESH1 Functions as a Metazoan PAPS Phosphatase to Regulate Sulfation. Nat.Chem.Biol., 2025
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation