9C6V

Crystal Structure of a single chain trimer composed of HLA-B*39:06 Y84C variant, beta-2microglobulin, and NRVMLPKAA peptide from NLRP2 (1 molecule/asymmetric unit)

Summary for 9C6V

• Entry DOI: 10.2210/pdb9c6v/pdb
• Related: 9C6W 9C6X
• Descriptor: NACHT, LRR and PYD domains-containing protein 2,Beta-2-microglobulin,MHC class I antigen, 1,2-ETHANEDIOL, GLYCEROL, ... (5 entities in total)
• Functional Keywords: hla class i histocompatibility antigen, b-39 alpha chain, beta-2-microglobulin, nlrp2, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 47102.16

Authors

Sharma, R.,Amdare, N.P.,Celikgil, A.,Garforth, S.J.,DiLorenzo, T.P.,Almo, S.C.,Ghosh, A. (deposition date: 2024-06-09, release date: 2024-09-04)

• Primary citation: Sharma, R.,Amdare, N.P.,Ghosh, A.,Schloss, J.,Sidney, J.,Garforth, S.J.,Lopez, Y.,Celikgil, A.,Sette, A.,Almo, S.C.,DiLorenzo, T.P.; Structural and biochemical analysis of highly similar HLA-B allotypes differentially associated with type 1 diabetes.; J.Biol.Chem., :107702-107702, 2024; PubMed: 39173948; DOI: 10.1016/j.jbc.2024.107702

Experimental method

X-RAY DIFFRACTION (1.7 Å)