9C1Y

Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 7-((3-(((4-(6-aminopyridin-2-yl)butyl)amino)methyl)phenoxy)methyl)quinolin-2-amine

Summary for 9C1Y

Entry DOI	10.2210/pdb9c1y/pdb
Descriptor	Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 7-{[3-({[4-(6-aminopyridin-2-yl)butyl]amino}methyl)phenoxy]methyl}quinolin-2-amine, ... (6 entities in total)
Functional Keywords	nitric oxide synthase inhibitor, heme enzyme, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	200846.62
Authors	Li, H.,Poulos, T.L. (deposition date: 2024-05-29, release date: 2025-06-11)
Primary citation	Weerawarna, P.M.,Rathnayaka, A.D.,Li, H.,Lewis, M.,Poulos, T.L.,Silverman, R.B. Discovery of Tetrahydrobiopterin Displacing Potent Neuronal Nitric Oxide Synthase Inhibitor with Unprecedented Binding Mode: Synthesis, Biochemical Evaluation, and Structural Characterization To Be Published,
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation