9C1Y

Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 7-((3-(((4-(6-aminopyridin-2-yl)butyl)amino)methyl)phenoxy)methyl)quinolin-2-amine

9C1Y の概要

• エントリーDOI: 10.2210/pdb9c1y/pdb
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 7-{[3-({[4-(6-aminopyridin-2-yl)butyl]amino}methyl)phenoxy]methyl}quinolin-2-amine, ... (6 entities in total)
• 機能のキーワード: nitric oxide synthase inhibitor, heme enzyme, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 200846.62

構造登録者

Li, H.,Poulos, T.L. (登録日: 2024-05-29, 公開日: 2025-06-11)

• 主引用文献: Weerawarna, P.M.,Rathnayaka, A.D.,Li, H.,Lewis, M.,Poulos, T.L.,Silverman, R.B.; Discovery of Tetrahydrobiopterin Displacing Potent Neuronal Nitric Oxide Synthase Inhibitor with Unprecedented Binding Mode: Synthesis, Biochemical Evaluation, and Structural Characterization; To Be Published,

実験手法

X-RAY DIFFRACTION (2.3 Å)