9C0K

Cryo-EM structure of glucagon-like peptide-1 receptor (GLP-1R)-Gs complex with Exendin-phe1

Summary for 9C0K

• Entry DOI: 10.2210/pdb9c0k/pdb
• EMDB information: 45087
• Descriptor: Glucagon-like peptide 1 receptor, Exendin-4, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (7 entities in total)
• Functional Keywords: glucagon-like peptide-1 receptor exendin-phe1 biased agonist, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 165427.30

Authors

Zhang, X.,Johnson, R.,Belousoff, M.J.,Danev, R.,Sexton, P.M.,Wootten, D. (deposition date: 2024-05-25, release date: 2025-06-11)

• Primary citation: Zhang, X.,Belousoff, M.J.,Danev, R.,Sexton, P.M.,Wootten, D.; Structural insights into the activation of GLP-1R by biased ligands; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.72 Å)