9BZR

Structure of Class A Beta-lactamase from Bordetella bronchiseptica RB50 in a complex with clavulonate

Summary for 9BZR

• Entry DOI: 10.2210/pdb9bzr/pdb
• Related: 9BZN
• Descriptor: class A Beta-lactamase, PenP superfamily, MALONIC ACID, N-(2-HYDROXY-4-OXO-BUTYL)-N-(3-OXO-TRANSPROPENYL)AMINE, ... (5 entities in total)
• Functional Keywords: lactamase, serine hydrolase, penp, csbid, center for structural biology of infectious diseases, clavulonate, structural genomics, hydrolase
• Biological source: Bordetella bronchiseptica RB50
• Total number of polymer chains: 1
• Total formula weight: 29315.21

Authors

Maltseva, N.,Kim, Y.,Endres, M.,Joachimiak, A.,Center for Structural Biology of Infectious Diseases (CSBID) (deposition date: 2024-05-24, release date: 2024-06-12, Last modification date: 2025-09-24)

Primary citation

Inniss, N.L.,Minasov, G.,Chang, C.,Tan, K.,Kim, Y.,Maltseva, N.,Stogios, P.,Filippova, E.,Michalska, K.,Osipiuk, J.,Jaroszewki, L.,Godzik, A.,Savchenko, A.,Joachimiak, A.,Anderson, W.F.,Satchell, K.J.F.
Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.
Microbiol Resour Announc, 14:e0020025-e0020025, 2025

PubMed Abstract: Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

PubMed: 40391899
DOI: 10.1128/mra.00200-25

Experimental method

X-RAY DIFFRACTION (1.4 Å)