9BY6

Crystal structure of the kinase domain of EGFR soaked with non-covalent osimertinib

Summary for 9BY6

• Entry DOI: 10.2210/pdb9by6/pdb
• Related: 9BY4
• Descriptor: Epidermal growth factor receptor, 1,3-PROPANDIOL, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide, ... (4 entities in total)
• Functional Keywords: egfr, kinase domain, oncoprotein, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 39212.36

Authors

Ashtekar, K.D.,Stayrook, S.E.,Lemmon, M.A. (deposition date: 2024-05-23, release date: 2025-05-28)

• Primary citation: Tsutsui, Y.,Ashtekar, K.D.,Stayrook, S.,Lemmon, M.A.; Comprehensive characterization of EGFR-tyrosine kinase inhibitor interactions probed by hydrogen-deuterium exchange and mass spectrometry (HDX-MS); To Be Published,

Experimental method

X-RAY DIFFRACTION (2.551 Å)