9BRM

Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL077-22

Summary for 9BRM

Entry DOI	10.2210/pdb9brm/pdb
Descriptor	G protein-coupled receptor kinase 5, (3Z)-3-[(4-{[(2S)-2-hydroxy-2-(oxan-4-yl)ethyl]carbamoyl}-3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2-oxo-N-[(1R)-1-phenylethyl]-3,7-dihydro-2H-indole-5-carboxamide (3 entities in total)
Functional Keywords	g protein-coupled receptor, gpcr g protein-coupled receptor kinase, grk kinase, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	69488.38
Authors	Chen, Y.,Tesmer, J.J.G. (deposition date: 2024-05-11, release date: 2025-11-12)
Primary citation	Chen, Y.,Tesmer, J.J.G. Structures of GRK5 bound to novel inhibitors To Be Published,
Experimental method	X-RAY DIFFRACTION (2.73 Å)

Structure validation