9BOX
Room-temperature X-ray structure of human mitochondrial serine hydroxymethyltransferase (hSHMT2) with PLP-glycine external aldimine and 5-formyltetrahydrofolate (folinic acid)
This is a non-PDB format compatible entry.
Summary for 9BOX
Entry DOI | 10.2210/pdb9box/pdb |
Descriptor | Serine hydroxymethyltransferase, mitochondrial, (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)glycine, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, ... (4 entities in total) |
Functional Keywords | pyridoxal 5'-phosphate, plp, fold type 1, one carbon metabolism, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 208428.34 |
Authors | |
Primary citation | Drago, V.N.,Phillips, R.S.,Kovalevsky, A. Universality of critical active site glutamate as an acid-base catalyst in serine hydroxymethyltransferase function. Chem Sci, 15:12827-12844, 2024 Cited by PubMed: 39148791DOI: 10.1039/d4sc03187c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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